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‎ 20.1001.1.17353351.1403.20.0.4.4

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Enhancing the biocompatibility of neural implants by applying advanced ceramic coatings containing protein
Ali Shanaghi * , Ali Reza Souri , Hanieh Shahriyari
Malayer University , alishanaghi@gmail.com
Abstract:   (512 Views)
Specific challenges are associated with the interaction of neural implants with human tissue and the central nervous system, primarily arising from the complex interactions between implant materials and the biological tissues of the nervous system. This paper examines the critical role of protein-containing ceramic coatings in enhancing the biocompatibility of these implants. Proteins on the implant surface and in the surrounding environment significantly influence the body's response to the implant, affecting crucial processes such as inflammation, cell adhesion, and tissue integration. Therefore, understanding the mechanisms and functions of these proteins in ceramic coatings is essential for improving biocompatibility. The design of ceramic coatings that incorporate proteins such as collagen and whey protein, inspired by components of the natural extracellular matrix, along with advanced surface modification techniques like self-assembled monolayers, hydrogel coatings, and nanoscale surfaces, can lead to the development of more effective neural implants. These coatings enhance the immediate tissue response to implants through surface chemistry, improve interactions between the implant surface and damaged neural tissue, and increase their stability and long-term performance. These characteristics are vital for various applications, including neural prosthetics, brain implants, and neurobiological research. Ultimately, this research underscores the importance of designing protein-containing ceramic coatings to improve the quality of life for individuals with neurological disorders and pave the way for more innovative treatments.
 
Keywords: Neural implant, Advanced ceramic-based coatings, Protein, Biocompatibility, Tissue engineering.
     
Subject: Bioceramics
Received: 2024/10/4 | Accepted: 2024/12/30
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